Investigation of antibacterial activities of sponge Axinella sinoxea’s extracts from Larak Island, Persian Gulf

Sponges are the most primitive and simplest multicellular animals. These organisms don’t have any mechanical defense system, so their early appearance in evolution has given them a lot of time for the development of advanced secondary metabolites as chemical defense system. Sponges have the potential to provide drugs from chemical components against diseases, such as antibacterial. Antimicrobial activity of Axinella sinoxea, collected from Larak Island in the Persian Gulf. The extracts were produced by Bligh & Dyer method, In vitro antimicrobial activity by Broth Dilution Methods against clinical gram-positives and gram negatives. The results conducted that the diethyletter and aqueous extracts didn’t have any antibacterial activities on Escherichia coli and Pseudomonas aeruginosa, but minimum bacterial concentrations (MBC) of the diethyletter extract on Bacillus subtilis spizizenii and Staphylococcus aureus aureus. Therefore secondary metabolites solutions in diethyletter, nonpolar- semipolar have antibacterial activity and it can be used for antibiotic producing.